I Pity the Full!

I Pity the Full! I Pity the Full! I Pity the Full! By Maeve Maddox Something odd has happened to the valuable articulation idiot proof. Numerous essayists are composing full evidence to mean safe against confusion, abuse, or disappointment: The most effective method to make an agreement full-confirmation Making A FULL PROOF MARKETING CAMPAIGN Diminish Stretch Marks From Pregnancy Try These Full-confirmation Remedies Steps to a Full Proof Insect Free House 10 Full Proof Methods On How To Make Easy Income Online! The articulation idiot proof began in 1902 as an Americanism meaning safe against the ineptitude of a blockhead. It consolidates the words nitwit and evidence. fool: an individual ailing in judgment or reasonability; an individual who acts moronically or wildly confirmation: The proof or contention that constrains the brain to acknowledge a statement as evident. Secure follows the example of such words as flame resistant and waterproof and implies that something has been verified to withstand certain harming operators. The developing utilization of the articulation full confirmation in the feeling of secure may originate from a hesitance to make offense the nitwit segment. However the definition in Merriam-Webster Unabridged dexterously figures out how to characterize secure without the smallest notice of the intelligence tested bit of the populace: Â ï ¿ ¼ idiot proof 1 : so straightforward, plain, or solid as not to be subject to be misconstrued, harmed, or abused 2 : ensured to work without breakdown or disappointment under any conditions There likely are settings in which the articulation full verification can be supported. For instance, one may request full verification of personality. In spite of the fact that I can't help suspecting that confirmation would get the job done. The articulation to make full confirmation happens in the King James interpretation of the Bible: †¨But watch thou no matter what, suffer sufferings, accomplish crafted by an evangelist, make full evidence of thy service. 2 Timothy 4:5 The articulation and conversations of its importance are to be found on numerous zealous destinations: What comprises â€Å"full proof† in Paul’s exhortation to Timothy? I think make full verification of intends to satisfy the service that God offers you to do. On the off chance that you simply cant bear to utilize an articulation that you dread may recommend youre considering somebody a simpleton, here are a couple of words you could substitute in specific settings: faultless trustworthy solid dependable certain sure ensured Need to improve your English shortly a day? Get a membership and begin getting our composing tips and activities day by day! Continue learning! Peruse the Expressions classification, check our mainstream posts, or pick a related post below:70 Idioms with HeartHomonyms, Homophones, Homographs and HeteronymsHow Do You Fare?

Language and society Essay Example | Topics and Well Written Essays - 250 words

Language and society - Essay Example The author doesn't welcome the way that if school graduates are sufficiently sharp, they can store all acquiring material and coursework to be at standard with online degree holders. The utilization of language to definitively communicate thought is obvious all through the article. He especially utilizes belief system to make assent in this way persuading the peruser that his angle is the better. Achievement is accomplished when the essayist clarifies that professional educations are just looked for after on the grounds that businesses favor them while enrolling. He gives an answer for the stalemate by giving a component that can be utilized to make online degrees much more speaking to bosses than professional educations. In doing as such, he adjusts his considerations to the qualities and wants of the general public to catch assent. Non-literal language is likewise utilized by the essayist to pass his planned message. For instance, the essayist says â€Å"Colleges are holding innovation under control because†¦Ã¢â‚¬  This imaginative utilization of language serves to lay accentuation on the way that it is school overseers who smother the pertinence of on the web

Symptoms of Oxycontin Withdrawal

Symptoms of Oxycontin Withdrawal Addiction Drug Use Opioids Print Oxycontin Withdrawal Symptoms By Buddy T facebook twitter Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Learn about our editorial policy Buddy T Medically reviewed by Medically reviewed by Steven Gans, MD on July 10, 2016 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Updated on October 27, 2018 Pureradiancephoto / Getty Images More in Addiction Drug Use Opioids Cocaine Heroin Marijuana Meth Ecstasy/MDMA Hallucinogens Prescription Medications Alcohol Use Addictive Behaviors Nicotine Use Coping and Recovery In This Article Table of Contents Expand Causes   Who's at Risk Symptoms Potential Dangers Treatment of Symptoms Withdrawal Period Long-Term Treatment   View All Back To Top Oxycontin withdrawal describes a wide range of symptoms that can occur after a person stops or dramatically reduces the medication after heavy or prolonged use. Withdrawal from Oxycontin is similar to withdrawal symptoms experienced with any opiate-based drugs such as heroin, morphine, Dilaudid, methadone, and codeine.?? Causes   Any opiate-based drug can cause physical dependence or addiction. If Oxycontin is taken over a lengthy period of time, you can build up a tolerance to it, meaning that greater amounts of the drug are needed to produce the same effect.?? If you have developed a dependence on Oxycontin and you try to stop or cut back on the amount you take, your body needs time to adjust and recover, and withdrawal symptoms can result. Whos at Risk Anyone who has taken Oxycontin over a period of time, usually several weeks or more, can experience these symptoms. It varies with the individual and can happen upon quitting or cutting down. This includes patients who have taken Oxycontin as prescribed to treat pain while recovering from surgery or an injury. Symptoms Oxycontin withdrawal symptoms can range from mild to severe, depending on how much and how long you have taken the drug. Some people who have only used the drug therapeutically may not even realize that they are experiencing withdrawal; many users  report thinking that they just have the flu.?? Withdrawal symptoms usually begin six to 30 hours after the last use of the drug.?? Early Symptoms of Oxycontin Withdrawal Include: AgitationAnxietyMuscle achesIncreased tearingInsomniaRunny noseSweatingYawning Later Symptoms of Oxycontin Withdrawal Include: Abdominal crampingDiarrheaDilated pupilsGoosebumpsNausea and vomiting Potential Dangers Withdrawal from Oxycontin use can be very uncomfortable, but it is not life-threatening. However, there are complications that can occur, which do pose a  danger. Aspiration can occur if you vomit and breathe in stomach contents into the lungs, which can cause lung infection or choking. Vomiting and diarrhea can cause dehydration  and chemical and mineral disturbances in your body. The biggest danger, however, happens if you quit taking Oxycontin and decide to begin taking the drug again. Because the withdrawal process reduces your tolerance for the drug, you can overdose on a much smaller dose than you usually took.?? Therefore, most overdose deaths occur in people who have recently withdrawn or detoxed from Oxycontin start taking it again and think they can tolerate the same amount they used to take. Treatment of Symptoms If you are planning to quit using Oxycontin after heavy or prolonged use, dont try to do it on your own. At the very least, make sure someone else is around to support and keep an eye on you as you withdraw. Contact your healthcare providers and let them know that you plan to detox from Oxycontin. They will explore and recommend one of a few different regimens used for detoxification, which can include the use of Clonidine to reduce anxiety, agitation, muscle aches, sweating, runny nose, and cramping.?? They can also give you other medications for vomiting and diarrhea. Withdrawal Period The severity and length of withdrawal symptoms will vary from individual to individual. The most uncomfortable symptoms should subside within a few days to a week. However, if you find that your symptoms last longer than seven days, you should seek medical attention. If you find that you cannot quit using Oxycontin in spite of your best intentions to do so, you may need to seek a professional treatment program to help you with your dependence. Long-Term Treatment   Many people who detox from Oxycontin find that they need long-term treatment following withdrawal to stay off the drug. This can include support groups, pharmaceutical treatment, outpatient counseling, or intensive outpatient treatment and even inpatient treatment programs.??

What Respect Is The Word Respect - 1113 Words

When talking about the word respect, numerous individuals have no clue what it implies. This word changes its meaning depending on who is inquired. Several people, even ones who comprehend what respect implies, still have no respect for anyone else. A two-way streak that everyone appears to overlook is respect. The word respect has a one-sided meaning to it, as an consequence of all the disrespect around the world. Respect has different opinions, gone through history, and help shape famous quotes. These days, numerous individuals have different implications for the word respect, however there is only one genuine meaning. The definition for the respect is as per the following, a feeling of deep admiration for someone or something elicited by their abilities, qualities, or achievements. Apperception, esteem, consideration, dignity, recognition, and honor are just a minority of the synonyms. So of course, criticism, dishonor, disrespect, neglect, disregard, and ignorance are just a minority of the antonyms. Indeed, even across the world, there are different definition for the word respect. Even throughout time this word has changed numerous times. This word has endless implications around the world and all throughout time. For instance, an elderly person might find it respectful for another person to help them cross the street while on the other hand they might consider it a sign of weakness. An example of how the word respect changes around the world, like in some areas ofShow M oreRelatedPersonal Essay : Self Espect And Self-Respect739 Words   |  3 PagesMerriam-Webster, self-respect is a proper respect for oneself as a human being. I do not call it self-respect when I constantly beat myself down with words. One must put themselves in a position of self-respect with self-acceptance, self-worth and self-conceit. Prior to this time in my life, I would continuously bully myself with malicious words. This hurtful content would come from my own self or others. I had a visual idea of what I wanted myself to be. At the time, self-respect did not look likeRead MorePersonal Statement On Self Respect1263 Words   |  6 PagesSelf-Respect When I think of the word â€Å"self-respect,† I think of understanding the importance of your own rights and sometimes looking out for your best interests before others. Of course, it is always great to put others before yourself at times; but when it comes down to it, you should never put yourself in a vulnerable position. When first hearing this word, I understood it as having pride and confidence in oneself. However since then I have learned that there’s much more to it. Digging deeperRead MoreRespect and Why the Marine Corps Has a Rank Structure. Essay1050 Words   |  5 PagesRespect and why the Marine Corps has a rank structure. There are very few things in the modern military of today or any military that has ever existed before our current military for that matter, that are more important than the rank structure and the the respect that is demanded of you by that rank structure. Those are two very important characteristics of every successful military unit. With added details here and there, in this essay I will mainly be discussing what respect actually is, howRead More The Importance of Respect in Our Society Essay509 Words   |  3 PagesThe Importance of Respect in Our Society Respect plays a role in our every day lives. When we go to school, theres respect. When we go to a restaurant, theres respect. When you go to your family reunion, there is respect. You may not notice it, but thats only because they are being respectful to you .If youre not respectful then you will be disrespected because your being mean. So you should always be respectful to others so they will treat you the way you want to be treated. Read MoreSelf Respect Is A Very Powerful Term1099 Words   |  5 PagesNeel Bhagat ENG 111 September 09, 2015 Self-respect is a very powerful term. Self-respect is something that has to be earned; it has to be earned from you for yourself. Self-respect has to be learned by oneself, nobody is born with self-respect for himself or herself; it’s not an instinct. Many people take pride in their sense of self-respect. Self-respect is a vital part of ones existence. Self-respect is developed throughout a persons lifetime through many different experiences and encountersRead MoreRespect vs. Disrespect1242 Words   |  5 PagesRespect Vs Disrespect By Osita Onyebuchi Respect vs. Disrespect Have you ever met someone who was rude to you and didnt hold you with much regard? How did you feel? Did you feel angry? What do you think respect is? How is respect earned? Respect is an important way of being kind and good to other people. We live in a society that respect is earned not given. With respect there is also an opposite side of disrespect. The definition of respect is to consider worthy of high regard. There areRead MoreRespecting Elders1547 Words   |  7 Pagesalways respect my elders, if I didnt, Id get a slap on my face by my parents. As I grew up, I came to realize the true meaning of the phrase, respect your elders, and I agree fully with my mothers teachings. I not only respected my elders, but I respected everyone around me. When I had my children, I taught them the same way my parents taught me, on how to respect their elders, and why. I never had any problems teaching my children how to respect, not only their elders, but how to respect everyoneRead MoreRespect1532 Words   |  7 PagesRespect Being responsible for what you do will earn you the respect you deserve, also doing what is right and not running your mouth demonstrate a lot of respect, â€Å"Being brilliant is no great feat if you respect nothing†. (Johann Wolfgang von Goethe) Every military in this world has some sort of chain of command in which respect is the main premise behind the entire Idea of organization and with a chain of command. Respect is important in the design of the military system itself. You haveRead MoreRespecting Elders1559 Words   |  7 Pagesalways respect my elders, if I didnt, Id get a slap on my face by my parents. As I grew up, I came to realize the true meaning of the phrase, respect your elders, and I agree fully with my mothers teachings. I not only respected my elders, but I respected everyone around me. When I had my children, I taught them the same way my parents taught me, on how to respect their elders, and why. I never had any problems teaching my children how to respect, not only their elders, but how to respect everyoneRead MoreThe Rattler Character Analysis790 Words   |  4 Pageshis innate respect for life and nature. The author uses imagery to characterize the snake and emphasize the importance of its life. When the narrator first approaches the snake, he observes how the snake â€Å"held his ground in calm watchfulness; he was not even rattling yet, much less was he coiled; he was waiting for me to show my intentions.† This description uses specific details of the snake’s actions to illustrate how the snake reacts nonviolently. In fact, the snake waits to see what the narrator

The Biggest Myth About Term Paper Writing Service in Uk Exposed

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The Logistics Industry Planning in Ruoqiang, Xinjiang Province Free Essays

string(261) " logistics nodes through co-ordinate and mathematic analyzing methods ; \( 2 \) Linear optimisation be aftering method: this solution’s advantage is its effectual optimisation technique, so normally it is adopted as a tool in strategic logistics be aftering\." The Logistics Industry Planning in Ruoqiang, Xinjiang Province Chapter 2: The Theoretical Review of the Logistics Parks’ Planning Theory 2.1 The Theoretical Review of the Logistics Parks’ Planning Method A long-run building period together with the complexness during building is the chief feature in edifice logistics Parkss. Constructing a logistic park demands immense financess, and it is non profit-making in a short clip. We will write a custom essay sample on The Logistics Industry Planning in Ruoqiang, Xinjiang Province or any similar topic only for you Order Now Now under a ferociously competitory market, it is even more of import to carry on the planning method analyzing, particularly when during the existent building procedure, tonss of problems’ arising are due to a deficiency of sensible planning methods. In China, such jobs and misinterpretations are: ( 1 ) blindly enveloping the land ; ( 2 ) little theoretical analyzing on logistics parks’ be aftering method ; ( 3 ) deficiency of be aftering footing ; ( 4 ) no clear cognition on logistics parks’ map ; ( 5 ) deficiency of in-depth probe on market demands [ 4 ] . 2.1.1 Logisticss Parks’ Planning Methods: Current Research Situation in Foreign Countries MSFLB Model: presently there are few foreign bookmans concentrating on logistics park be aftering methods. The chief planning methods are summarized by the Fraunhofer Research Institute of Germany. They studied many typical international logistics parks’ planning and building procedure and summed up the common characteristics as five stairss. MSFLB are in fact the acronyms of the undermentioned five stairss: Market Study, Strategic Positioning, Function Design, Layout Design and Business Plan. 2.1.2 Logisticss Parks’ Planning Methods: Current Research Situation in China ( 1 ) Planing method based on Highway Transportation Network: by following a â€Å"two-stage† perusal method, the research worker foremost locate the site of logistic park harmonizing to metropolis logistic volume and distribution characteristics. Then in phase two, based on the rule of minimum logistic and route web capacity-expansion cost, they bring in the bi-level scheduling theoretical account to set urban logistic park planning into the whole urban transit web planning system, so as to reflect the route network’s influence to the layout of urban logistic Parkss. [ 6 ] ( 2 ) Planing method based on the Industrial Park: this planning method follows a series of phases such as map placement, planning and planing construct, map construction, and route traffic organisation construct. Each of the above-named phases besides contains a series of act uponing factors severally, so this planning method is a particular 1. [ 7 ] ( 3 ) Planing method based on urban installations: the interior decorator adopts the urban planning method to carry on logistics Parkss undertaking. The metropolis map orientation, layout planning, transit planning and a series of other specific be aftering methods are applied into the logistics parks be aftering procedure, so as to do certain it goes on smoothly and comprehensively. ( 4 ) Planing method base on weight coefficient: Chinese bookman Zhang Qian considered the chief factors of the regional distribution park and by utilizing nonsubjective rating method, he set up a regional distribution park planning theoretical account. Then by carry oning an overall rating on regional distribution park’s planning based on weight coefficient, he fixed the optimum strategy and applied this chosen strategy into existent planning of logistics Parkss. [ 9 ] 2.1.3 Current Research Situation of the Logistic Parks in Xinjiang Province By and large talking, the economic development in Xinjiang state still remains comparatively developing, and therefore a spread does be between other eastern states and Xinjiang in logistics industrial development. Presently, there are several Chinese bookmans concentrating on the perusal of the logistics industry development in Xinjiang state. Scholar Tangmin from Xinjiang University published his article â€Å"A Study on the Relationship between the Logistics Industry Development and the Economic Growth in Xinjiang Province† , in which he studied the logistics overall state of affairs, supply and demand state of affairs in Xinjiang, based on Xinjiang’s regional characteristics and economic development degrees. He besides conducted a qualitative and quantitative research on the relation between logistics development and economic growing, and gave several suggestions on how to advance the logistics industry development in Xinjiang state [ 10 ] . Fangmin and Ying Shaomin in their article â€Å"Thoughts on the Informatization of the Logistics Industry of Xinjiang Province† pointed out the necessity to transport on the informatization building procedure every bit good as offered some suggestions [ 11 ] . Wu Jing from Shihezi University listed some jobs in Xinjiang logistics industry development in his article â€Å"Research on Logisticss Industry and Economic Development in Xinjiang Province† , and offered some practical solutions. Ge Ju and Jiang Zhiqing in their article â€Å"Prediction and Analyzing on the Logistics Demand in Xinjiang Province† pointed out the influential factors of logistics demand based on their analysis on the features of the logistics industry in Xinjiang [ 13 ] . From the literary reappraisal above, it is clear that many bookmans have already conducted research on Xinjiang logistics industry. However, a practical logistics park be aftering method suitable for the economic development and run intoing the m arket demand in Xinjiang state has non yet been formed. 2.1.4 Analysis on the Planning Method 2.1.4.1 The Concept of the Planning Method and the Current Theories Planing method has ever been highlighted since the center of the 19Thursdaycentury, and the innovators are some bookmans analyzing land economic sciences and regional geographics, such as Edgar Hoover, Johann von Thuen, August Loseh, Melvin Greenhut, Walte Isard and T. Palander. In be aftering determination procedure, transit cost was the common topic for those earlier surveies. Though many constructs were already formed under the status in agricultural and pre-industrial society, but those bookmans still used them. The betterment and development of the topics of operational research and logistics provide opportunities for installations be aftering method, which were therefore non limited to pure theoretical surveies ; alternatively, more practical mathematical theoretical accounts were set up. During the planning procedure, the undermentioned methods are normally adopted: ( 1 ) The mathematic analysis planning method: this solution combines weight and distance, seting the two factors as the co-ordinate points, and logistics nodes the variables. The concluding solution strategy is to find the coordinate place of the logistics nodes through co-ordinate and mathematic analyzing methods ; ( 2 ) Linear optimisation be aftering method: this solution’s advantage is its effectual optimisation technique, so normally it is adopted as a tool in strategic logistics be aftering. Under certain restraints, this method could assist you take a best solution strategy from many options. ( 3 ) Analog simulation engineering be aftering method: this solution could set the computer’s 3-dimensional simulation engineering into the existent application in logistic parks’ planning and designing, and repair the planning of logistic nodes. At present, there are two simulation engineerings, viz. , inactive simulation and dynamic simulation. 2.2 The Theoretical Review of the Logistics Parks’ Planning Technology In logistic Parkss be aftering, now many bookmans at place and abroad hold made intensive survey about the following four parts: demand anticipation, site choice, land scale confirming and park map. Many of their research findings have been put into practical usage successfully, and we have got some successful instances for our mention. Therefore, this paper will give you a literary reappraisal on these theoretical research consequences every bit good as some successful instances. 2.2.1 Logisticss Parks’ Planning Technology: Current Research Situation in Foreign Countries 2.2.1.1 Planning Technology of Demand Prediction ( 1 ) Multinomial Probit Model: Scholar Rodrigo A. Garrido and Hani S. Mahmassani ( 2000 ) have forecasted freight transit demand with the space-time polynomial probit theoretical account [ 14 ] . ( 2 ) Multivariate Cointegrating Vector Auto Regressive Model: Mudit Kulshreshtha and other bookmans have made the cargo clip sequence informations as their research aim, evidenced by field survey on Indian railroads. They introduced the multivariate cointegrating vector car regressive theoretical account into freight conveyance demand anticipation. 2.2.1.2 Planning Technology of Site Selection Sing the site choice theory and method survey of logistic Parkss, few instances could be applied for our mentions. At present, some research consequences are related to distribution centres, logistic centres and warehouse location, while in bing foreign paperss, there is barely any reference about the footing debate on logistic parks’ site choice. 2.2.1.3 Planning Technology of Land Scale Confirming ( 1 ) Operational Research Model: based on operational research theory, bookmans such as Weber [ 16 ] ( 1929 ) , Beckman [ 17 ] ( 1968 ) and Drener [ 18 ] ( 1995 ) have made surveies on logistic Parkss land graduated table. ( 2 ) Integral Programing Model: Scholar Noritake and Kimura [ 19 ] ( 1990 ) have brought frontward the built-in scheduling theoretical account to gauge haven logistics land graduated table. 2.2.1.4 Research on the Function of Logistic Parks’ Planning In comparing, presently more researches have been conducted on the micro-layout planning of the logistic park than on its internal map planing [ 20-21 ] . 2.2.2 Logisticss Parks’ Planning Technology: Current Research Situation in China 2.2.2.1 Planning Technology of Demand Prediction ( 1 ) Unary Linear Regression Analysis Model: base on value volume and nonsubjective volume, Chinese bookmans Liu Changxiu, Zhang Wuyi and Lin Qiang chose the unary additive arrested development analysis method to calculate the comprehensive lading volume of Yunnan state and demonstrated that the entire logistics cost of Yunnan state appeared an increasing inclination with rapid growing of comprehensive lading volume [ 22 ] . ( 2 ) Grey Prediction Model: Chinese bookmans Han Yanhui, Wang Yanlin and Chen Chao analyzed the types of chief industries in Erduos part and predicted the end product of ladings of chief industries with gray anticipation method. The consequences showed that the end product of ladings of chief industries would maintain fast increasing velocity in the hereafter [ 23 ] . ( 3 ) MATLAB Software Model: Chinese bookmans Tang Zhongming and Fu Xinping illustrated the basic rule of using MATLAB package to foretell logistics demand, and successfully conducted a rapid anticipation on cyclicity inclination logistics demand on the MATLAB platform [ 24 ] , and forecasted freight transit demand with the space-time polynomial probit theoretical account [ 14 ] . ( 4 ) MLP Neural Network Forecasting Model: base on their surveies on MLP unreal nervous web, Chinese bookmans Hou Rui and Zhang Bi brought a regional logistics demand calculating theoretical account. This theoretical account non merely explained the nonlinear relationship between regional economic system and regional logistics demand but besides put frontward a new thought and methodological analysis for regional logistics demand calculating [ 25 ] . ( 5 ) Combination Forecasting Model: based on the rule of the least mistake absolute value, Chinese bookmans Chu Liangyong, Tian Zhiguang and Xie Xinlian combined the arrested development analysis, Grey prediction and nervous web to organize a combination calculating theoretical account in logistics demand. They verified the theoretical account with concrete illustration. The consequence of mistake analysis showed that it well improved preciseness of prognosis and manifested the cogencies of prediction of logistics demand [ 26 ] . 2.2.2.2 Planning Technology of Site Selection ( 1 ) Center of Gravity Method: Chinese bookmans Wang Qionglin and Zhang Tingting used Goolge Earth package and carried out the logistic parks’ site location by utilizing the method of center-of-gravity. They besides evaluated each campaigner reference by fuzzed comprehensive rating method to deduce the optimum reference [ 27 ] . ( 2 ) Factor Analysis Method: Chinese bookmans Zou Xiaoping and Guan Dongmei put frontward the method of taking Logistics Park by factor analysis method. Using this method, the music director first chooses each campaigner address’s act uponing factor, so they grade each campaigner strategy based on those factors, and at last, they calculate the entire points of campaigner strategy, viz. , the whole weight of the campaigner strategy. The concluding site strategy is the 1 with the highest entire weight [ 28 ] . ( 3 ) A-F Method: based on combing normally used comprehensive rating methods in logistics Parkss location, Chinese bookmans Ji Dan and Guo Zheng made comparative survey on many factors, and they drew the decision that each individual rating method has its ain advantages and disadvantages, therefore they should be integrated, in which the A-F method ( Analytic Hierarchy Process and Fussy Comprehensive Evaluation Method ) has a comparatively better publicity value. ( 4 ) CFLP Model: Chinese bookman Xu Chengtie, Zhu Xiaoning and Xu Xiaobing analyzed the rules for distribution-centered logistics parks’ be aftering and based on this, they suggested the CFLP ( Capacitated Facility Location Problem ) theoretical account and offered a quantitative processing method for site location job [ 30 ] . ( 5 ) Non-Structural Fuzzy Optimal Model: Chinese scholar Tan Minjun and Wang Xiong comprehensively considered assorted factors act uponing the logistics Parkss site location in the decision-making procedure. By utilizing a non-structural fuzzy optimum theory, they fixed the campaigner references weight and determined the concluding site by the size of each vector measure [ 31 ] . ( 6 ) Combined Evaluation Model: Chinese bookmans Zhang Dezhi and Xie Ruhe offered a combined rating theoretical account. Compared with former traditional calculating method, this theoretical account enjoys a better pertinence [ 32 ] . 2.3 Brief Summary of this Chapter This chapter is the theoretical portion of the whole thesis. First, a theoretical literary reappraisal on logistics parks’ be aftering methods is given and the writer makes a comparative analysis on the typical logistics parks’ be aftering methods at place and abroad, summaries the features of those be aftering methods and specifies their Scopess of application. Then, a theoretical literary reappraisal on logistics parks’ be aftering engineering is offered. The writer surveies on the planning technologies’ current research state of affairs from the following four facets: demand anticipation, site choice, land scale confirming and the map of logistics parks’ planning, so the writer analyzes the four planning technologies’ importance grade. Finally, based on the elaborate theoretical literary reappraisal on logistics parks’ be aftering method and engineering, this chapter lays the foundation for the planning method of Xinjiang logistics Parkss. How to cite The Logistics Industry Planning in Ruoqiang, Xinjiang Province, Essay examples

The Yellow Wallpaper By Charlotte Gilman

Introduction ‘The yellow wallpaper’ by Charlotte Perkins Gilman Gwynn is an intriguing story of a sick woman, Charlotte Perkins, confined in a room for treatment by her husband, a physician.Advertising We will write a custom essay sample on The Yellow Wallpaper By Charlotte Gilman specifically for you for only $16.05 $11/page Learn More Charlotte is suffering from neurasthenia. Cared by his overprotective physician husband, but instead treats the care and concern as unfair for confinement and a twenty-four hours bed rest prescription. Charlotte sickness makes her realize that nobody can listen to her ideas; she resorts to write secretly in her daily journals as a way of expressing her compliments to somebody. On few occasions is she allowed visiting other people, in fact those she visits are her husband’s suggestion, who are normally usual close family relatives, those she suggests her husband turns them down. There is a clear misunde rstanding on care, love and concern between the patient and the physician. The Yellow Wallpaper Persuasion Essay The fact that the patient is the physician’s wife ought to portray a picture of mutual agreements and understandings rather than subjecting ones decision to the other with a reason for care and protection. A small inclination to the husband’s decisions is better, but a usual put off to charlotte’s ideas causes misunderstanding. However, she pursues on the wallpaper finding to get a clear clue of what is affecting them all, especially her husband the sister in law. With the nervous breakdown all the ideas and suggestions that charlotte comes up with, with a view of positive response are against his husband’s final decision â€Å"†¦. there is something strange about the house — I can feel it. I even said so to John one †¦.but he said what I felt was a draught, and †¦Ã¢â‚¬  (Gilman, 2001, p.2). The husband is thinking out o f prejudice, which is the real cause of misunderstandings in the context. Although the misunderstandings brought about by the idea that she might be suffering from brain disorders it does not really mean that she is wrong all the time. She gives a comment that even the reader succumbs to when she says, â€Å"Personally, I disagree with their ideas. Personally, I believe that congenial work, with excitement and change, would do me good† (Gilman, 2001, p.1). With such a sickness one can show care by undertaking congenial work with the patient but the husbands sees it as very wrong. The physician portrayed with a domineering character has shown negligence to her wife psychological support. This is from the misinformation of how sick Charlotte is. She believes that she is not very sick. Yet, her husband knows she is in a critical condition that does not allow her to think or give compliments â€Å"†¦ but John says the very worst thing I can do is to think about my condition , and I confess it always makes me feel bad† (Gilman, 2001, p.1).Advertising Looking for essay on american literature? Let's see if we can help you! Get your first paper with 15% OFF Learn More The misunderstanding is portrayed again when Charlotte is awake all night long. Her husband does not talk to her in most of the times, he thinks she will be stressed and worsen her situation. On the other hand, Charlotte has always longed for days when they will have some nice talks and discussions with her husband. When she tries to bring up a topic to shift houses she is put off with an excuse that it was not time for such a discussion. She goes back to bed but does not sleep, rather just stares at the moonlight (Gilman, 2001, p.8). Symbolism Gilman has given well-elaborated insights on the meaning of the Yellow Wall Paper. â€Å"She has done this in a slow yet steady pace to release the metaphors that are a clue to the Yellow Wall Paper as a symbol of her husbandâ€⠄¢s authority and dominance† (Gwynn Zani, 2007, p.71). It just begins with the main character’s fascination of the ugliness of the Yellow Wall Paper. The use of imagery has been well tuned to bring out the aspect that is feminism. While one might argue that too much use of this has made the story complex and hard to understand, it has helped bring home the intended agenda. â€Å"One of the images found in the paper tends to change with different lighting† (Gwynn Zani, 2007, p.71). This is meant to depict her husband as inconsistent in handling matters especially those that directly affect her. Conclusion The plot and characters in the story confirm that the misunderstanding is caused by misinformation of the patient’s real status and fear of his attention to involve her in anything other than the treatment. No wonder Charlotte goes after her pursuit secretly, to get the creeping woman, if she attempted to reveal to anyone then she could not realize it. S he even keeps her daily journal secretly for the same reason. The use of the first person narration has worked well in bringing home the main theme as it evokes the reader’s emotions to empathize the thesis; the husband’s love misunderstood for confinement in the room and care misunderstood for deterrence from involvement in other activities and thoughts that may worsen the condition. References Gilman, C. (2001). The Yellow Wall-paper. Ragged edge Online. Retrieved from http://www.raggededgemagazine.com/0701/0701lostclass1.htm Gwynn, R.S., Zani, S.J. (2007). Inside literature: Reading, responding, arguing. New York: Pearson Longman.Advertising We will write a custom essay sample on The Yellow Wallpaper By Charlotte Gilman specifically for you for only $16.05 $11/page Learn More This essay on The Yellow Wallpaper By Charlotte Gilman was written and submitted by user Jordyn D. to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Tips to Make Learning German Easier

Tips to Make Learning German Easier The first time most of us come in touch with a foreign language or at least with the need to study it, is in school. But learning a language in school is like learning to swim in one of those Japanese public swimming pools. It is simply an artificial situation and all efforts to make learning a language in a group worth everyone’s while are pretty much bound to fail. They call it the conversational or interactive approach. But isn’t using a language always interactive? And is a classroom really the right place to practice a language? Wouldn’t it suffice to instruct learners on how to learn it own their own and how to find a way to put it to good use? Overhaul your Learning Techniques Most of us get by in school as our brains are learning and survival machines. But only rarely have I come across someone who has actually learned how to learn a language. We all still often rely on those techniques that we have acquired or developed on our own in those times because they simply worked well enough. And it is these learning strategies that you might still use to learn German nowadays. But with the difference that nowadays it is not to improve your grades or to make your parents proud, but to deal with a real live situation. There are but there are two elemental factors that make a significant difference when you are learning German. The Main Keys to Success in German Language Learning The first thing that I demand from every learner is that they will take an exam at the end of our cooperation. And although this goal is just part of their success, it sets a very clear direction, enables us to develop a structure for our actions and sets a measurable time limit to our efforts. Without a clear goal and structure, any language will simply be overwhelming. There are thousands of words to learn, the grammar, and German grammar, in particular, seems impenetrable. When we try to speak we feel like there’s goo coming out of our mouths.   Setting up an exam date right away  does wonders for your learning. The problem is that we usually have no idea how long it will take us to reach a certain level. And that’s why I always recommend†¦ Get a Guide You are not the first to learn another language and there have been many men and women pulling their hair out over the question of how we can learn a new language the most efficient way. Some pulled a bit stronger and came up with miraculous methods which very often claim to teach you a language with very little effort and/or in very little time. Needless to say, you’d better refer to your gesunder menschenverstand, your common sense, when you come across anything that seems too good to be true. Good teachers are among the most undervalued people in this world. If you find a good teacher, you have an invaluable companion by your side. She will fight off the wolves, pick up the pebbles and thorns from your barefoot path and get you to just go a few meters farther when you waver and doubt whether you can reach your goal which still seems so far away. She is your walking cane, the whistled tune on your lips and the umbrella when it rains.   Of course one could also learn German on one’s own with ones proven techniques but I can state that from my experience, learning German with a tutor and with a clear goal makes a big difference. You will still have a lot of work to do but you will suffer significantly less.

3 Uncommon Ways To Get Team Buy In Every Time

3 Uncommon Ways To Get Team Buy In Every Time You probably already know a few of the tips and tricks to getting team buy in to new ideas, processes, or change. When it comes to influencing your peers, though, it can be a delicate dance. Because you lack positional authority, you cant pull the, Well, thats the way were going to do it, card. (Not that you ever would 😉) But these three off-beat tactics Im sharing will work for you. Today. Well lay some groundwork first. But if you wanna jump ahead, be my guest. Each strategy will work for peer or team buy in. Table of Contents: The Problem: Why We Resist Change? The Solution: What Does Leading Change Look Like? Step 1: Take the Marketing Cholesterol Test Step 2: Start With the Problem Step 3: Script the Critical Actions Required3 Uncommon Ways To Get Team Buy In Every Time via @ Did Isaac Newton Already Figure Out Why We Resist Change? Neurologically, were hard wired to maintain things as they are via our ingrained habits. Were comfortable in the rut of status quo. And any threat to it is perceived as discomfort - which humans avoid tooth and nail. Said psychologist Ralph Ryback: Inertia, or a tendency to do nothing or to remain unchanged, is at the headwinds of any change that we make in our lives. Wildly enough, Isaac Newtons principle of inertia applies to our psychology as well as the world around us. One of the best places to validate this is in the world of software - in both simple and complex ways. Remember when Spotify changed its hue of green a few years ago? Millions of us were used to their funky green. It wasn’t beautiful, but it was normal. Then, they warmed up the color in favor of the vibrant lime green. Thousands of users whined at the ugly new color scheme. I’ll admit, I didn’t like it at first either. Oh yeah†¦ then there’s the Snapchat UI updates that just about broke the internet. People hated the updates so much, there were riots in the streets! Okay, not quite that bad. But, the backlash was so intense, 1,257,640 users signed a petition on Change.org to get the old UI back. On a societal scale, people are change averse. We often have negative initial reactions to both functional and visual changes. This means â€Å"different† is often perceived as â€Å"bad.† The perception that different = bad often blocks positive organizational change. Learn how toThis isn’t simply a mob-mentality issue, either. It’s a human phenomenon at scales both large and small. As Mark Twain famously quipped: Im in favor of progress; its change I dont like. What Does Leading Change Look Like For Marketers? In user experience design, this is known as change aversion: Change aversion is the negative short-term reaction to changes in a product or service. This happens in the non-digital world, as well. And is a force we marketers have to battle when leading change (especially within our own companies). Now, lets learn how to go out with the old and in with the new. One of the most important changes marketers should make is killing makeshift marketing. Makeshift marketing has become the normal way marketers do things today. Its the pain of using one tool for social media scheduling Another tool for analytics A spreadsheet for tracking Endless email threads for collaboration and communication A task management tool (or multiple ones if everyone on your team uses something different) We get caught in a mess of using tons of different productivity tools that end up strangling our output rather than boosting it. Another force at work is that complicated tool stacks are actually celebrated with awards. To bring it a little closer to home, lets ask a question. You’re executing marketing today How’s that going? Staying organized is really hard. You’re missing deadlines, your team is disgruntled, your boss is wondering what’s happening, and stakeholders like your sales reps are constantly asking where their projects they requested three months ago are at. You can’t blame them. If you worked with another team, you’d expect things to roll forward smoothly, too, right? The thing is†¦ if you don’t change anything, you’ll keep experiencing these same side effects of â€Å"good enough-ism.† And that means†¦ You’ll continue to be frustrated†¦ You’ll continue making your peer managers frustrated†¦ You’ll burn yourself out with the trivial minutia of consistently missing deadlines Overcoming Change Aversion In Your Team However, everyone is used to the way things are. So, if youre going to overcome the forces allied against you as a leader, youve gotta be armed with the right strategies. So lets tackle three off-beat ways to overcome change aversion. Obliterate the status quo. And become a more influential leader while youre at it. #1. Take The Marketing Cholesterol Test To Get Team Buy In To start, you might need to prove that change is actually required right now. When you create urgency, at least people can agree that, We need to do something. One ingenious assessment for your organizations need to change appeared in the Harvard Business Review, and is called the Corporate Cholesterol Test. You can check out the original test in the article Change For Changes Sake. But heres an adaptation for us marketers to use. The tests purpose is to assess how well your teams (or team members) are working together. Thus Measuring how high your collaborative cholesterol is 😠· How high is your marketing cholesterol? Find out what that means and learn the answer viaTo do this, you can use Google Forms  to create a survey. Each of your peer managers should get the questionnaire to fill out. The test starts the buy-in process by helping your peer managers see for themselves if change is needed. Youll create three sections. Each with three yes or no answers. How well do we communicate? How well do we work together? How are our collective results? Pro Tip: To get honest answers, you can nix requiring first and last name. And simply make answers anonymous! Section One: How well do we communicate? In section one, youll ask these three yes or no questions: Do our teams interact only with people in their own group? This questions identifies the presence of silos.A silo mentality occurs when several departments or groups within an organization do not want to share information or knowledge with other individuals in the same organization.Basically its a problem of key info staying stuck in one group rather than shared with others it could help. Are there breakdowns in communication caused by silos? If there are silos, this will be a big fat yes 😕This is a great opportunity to understand it as a source of frustration. And you can position your change as a cure. Has fluid collaboration between our teams decreased over the past 6 months? This is an easy way to gauge how well your teams have worked together. If this is a Yes, its another sign that the winds of change should be blowing! How can marketers know theyre influencing positive organizational change? Find out via @Section Two: How well do we work together? In section two, youll ask these three yes or no questions: Are any people on your team uncomfortable with change? Now, admittedly, this question is a double-edged sword âš”ï ¸ After all, change is uncomfortable for pretty much everyone. But, as Sujan Patel writes, this is crucial to success.The crux of this question is to bring to mind the proverbial roadblocks to changeThe people on their team whose automatic answer is, No. Do we have processes, workflows, and tools that align with one another? I know this is buried in the middle of the survey But its my favorite question.This digs into the heart of a central problem for marketers today. We call it makeshift marketingand think of it as the temporary, sub-optimal solution for getting your marketing sh*t together. This is not #fakenews.I cant tell you how many marketers Ive met whose solution for â€Å"keeping their sanity† involves spreadsheets organizing spreadsheets.Who’ve decided endless meetings to â€Å"get on the same page† is par for the course.Who’ve succumbed to â€Å"on the fly† project management because that’s just the nature of the job?!And who’ve settled for a cobbled mess of one-trick tools becausewell†¦?Thats just how marketing works 😠¢In fact, this is one of the biggest problems solves (you can snag a free 1-on-1 demo to learn how it can help you do this!).Teams pay a HUGE productivity tax for misaligned processes, workflows, and tools.If this is a yes, its a red flag 🚠© Do your teams resist collaborative projects with other teams? Heres a newsflashIf people on your peer managers team resist collaboration, its prolly not because theyre bad people. Or employees.Did you know that 85% of most workers time is spent in email, meetings, and being on the phone?So maybe they resist working with other teams because they have so freaking much to do and not enough time!^^^ Sound familiar to you?If this is the case, its time to get efficient and make better use of peoples time.After all, who would resist: Here, would you like less stress while getting your time back and feeling more valued?If youre leading the right change, this can be exactly what youre giving them.What if collaboration could be a source of excitement and growth rather than a drain? Section Three: How are our collective results? In section three, youll ask these three yes or no questions: Has your team hit 80% or more of its KPI goals in the past 3 months? Simply put, if teams arent hitting their goals for more than 3 months in a row - somethings gotta change.This is a chance to highlight how your suggested change can help everyones tide rise. Have your teams collaborative projects proven positive ROI? This is an interesting one. Because some of your peer managers might say, What collaborative projects?Again, this could stem from silo issues Or signal a breakdown in teams working together.For instance, nearly every modern marketing teams should be working with developers (who are often outside their team) regularly.Next, if they have worked with other teamsWell, has it worked?Are there more dollars, email signups, or whatever else they were looking for because of the joint venture? Does anyone on your team (including you!) experience significant stress or anxiety when executing a new project? I absolutely love this question.While there is always *some* amount of stress kicking off a new project - it shouldnt be consistently significant.Scientifically, we know significant stress reduces productivity. It also promotes negative behaviors like procrastination. So if new projects give your team a panic attack, something major is broken.Now is the time to fix it. How To Score Your Marketing Cholesterol Test (In GIFs) Alright, heres the final reveal Score your test responses as follows: 0–2 yes answers Youre good and probably rock at getting your peers to buy in. 3–7 yes answers Right now is the perfect time for change! Saddle up and get it done. 8–9 yes answers Panic. It was time to change yesterday but today is good too. You got this  Ã°Å¸ ¤Ëœ #2. Start With The Problem To Get Team Buy In Next,  to overcome change aversion with your peer managers, start with the problem you’re trying to solve and the benefits your solution offers to them. Yes I’m encouraging you to market change to marketers. #inception Software has more to teach us, here. Intercom recently revamped the design of their products inbox - a place their customers spend a lot of time in. The new interface looks like Evernote and Intercom had a baby And its one cute baby. They got ahead of change aversion by focusing on problem their change was geared at solving. Often, change is resisted with statements like this: We dont need to change for changes sake! If you begin with the problem, though, you sidestep this as an issue altogether. When theres a genuine problem to be solved, you arent changing for changes sake. Your changing for growths sake. Huge difference. Trying to influence positive change within your marketing department? Start with the problem first. Start With The Problem First, specifically outline the problem you want to solve and the harm its causing. Outline the problem as specifically as you can: Right now, were using six different tools to manage our marketing. Because of the constant shuffle, details are getting lost, were dropping balls, and not hitting deadlines. Outline Your Solution Propose your solution, address the cost of switching, and focus on the benefits: If we consolidate our tools, these problems will evaporate. We each lead talented, competent teams. So its a simple thing to give them a better way to do their jobs. Yes, this will mean adapting our workflows to a fresh way of doing things. And it will mean a new way of collaboration among our teams. But the gain in productivity and organization will pay dividends in results, reduce stress, and improve communication. When you focus on the problem, your proposed change isnt the focal point. Admittedly, Im assuming the change you want to lead is truly an issue. If it is, you can position any resistance to be against the benefits your solution offers. This keeps the conversation focused on, How do we solve this  real problem. #3. Script The New Actions The Change Requires To Get Team Buy In A third way to  get your peer managers to buy in comes from Chip and Dan Heaths fantastic book,  Switch: How To Change Things When Change Is Hard. Its a way to get ultra-specific about what needs to happen next. The catchphrase analysis paralysis turns out to be a real thing. It even happens to LeBron James. When people are presented with too many options, we get stuck. When people are presented with too many options, we get stuck.Analysis Paralysis Is A Real Thing In the book  Switch, the authors share how this same phenomenon happens to doctors. A medical doctor and a psychologist devised a test to see how well the average doc make choices. The test involved two similar groups asked to make a decision on the same case. The only difference was that Group A made a choice between two options. While Group B had three. Check out the scenario The patient in the test was an older gentleman with hip trouble. Group A had to decide between a hip-replacement surgery and a simple medication that hadnt yet been tried. Almost 50% of the doctors from Group A chose the non-surgical path. Group B had a similar choice. Only instead of one non-surgical option, there were two. Thats it. That was the only variable. These doctors had to decide on surgery, medication 1, or medication 2 Logically, two non-surgical options seem even better than one, right? Well, only 28% of Group B docs opted for the non-surgical option. ^^^ This is analysis paralysis at work.

Role of domestic concerns in us withdrawal from vietnam Essay

Role of domestic concerns in us withdrawal from vietnam - Essay Example After analyzing these questions, we can finally land on our ultimate target that was to investigate the extent to which the domestic concerns played their part in the withdrawal of the United States of America. As rightly quoted by Jose Padilla, war is not really something at the sole discretion of the president, rather it is the public power that should ultimately shape the foreign policy of a nation, or more precisely, the fate and destiny of the nation. This thought truly reflects in the US Vietnam war. This war proved that it's the public, the common man of the nation, who will decide the foreign policy of the nation. The history recorded that the people protesting on the roads of New York or the colleges of Ohio forced the think tanks at Pentagon and Whitehouse to change their policy and finally withdraw from the tiresome and simply lost battle of Vietnam, that proved to be the graveyard for the human and the monetary resources of American nation. Almost all the historians do agree to the fact that domestic concerns forced the US Think Tank to finally decide to withdraw from the battle at Vietnam. However, the perception of the extent to which the internal factors played their role in that historical decision is different for different historians. Furthermore, the recorded evidences also tell that the ratio of favour for the war also differed from time to time, even during the war period and age group to age group as well. 2 The Vietnam War, which lasted in 1975 is also known as Indochina war, the American war in Vietnam and the Vietnam Conflict. Why did the United States of America tried to involve in the Vietnam If looked from a narrow perspective, it seems that this was just a conflict between the communist and the non-communist factions of the Vietnamese nation. However, when we take into account the entire global scenario at that time, especially that of post-world war and cold war, we tend to realize that it was not an ordinary civil war, rather a contest between the two opposing super powers of the time, both the powers claiming to be the super power but propagating entirely different ideologies of economics, religion and state governance. Thus it was a war between the communism and the socialism, the United States of America, along with its capitalist allies and the South Vietnam on one side and the Soviet Union, its allies, the People's Republic of China, and North Vietnam on the other. Thus, withdrawing from war does not only mean the inability to handle some civil war, had it been the case, United States of America would have left the battle far earlier than it did, but this withdra wal would probably have been seen by the United States of America's policy makers as the surrender to the communist alliance. This may well be attributed to the reluctance of the United States' think tank to withdraw at an earlier stage. What approach for the involvement was there in the mind of the military and political leadership of the United States of America Since this was not too long that the Second World War had ended, those American and other nations, who had witnessed the disastrous effects of war were still alive. Any war in any part of the world is thus supposed to get a furious reaction of the public. Specially when it comes to the war in United States of

Plea-bargaining Essay Example | Topics and Well Written Essays - 750 words

Plea-bargaining - Essay Example The advantage of this system is that there is no need for a trial, a right that the defendant waives losing the chance for acquittal. However, the defendant â€Å"escapes† with a lesser charge than would have been the case had trial been done. The state saves on the cost of conducting a trial (Grossman & Katz, 1983). For the system to be operational, there are issues that are pre-negotiated including the reduction of charges, recommendations regarding the sentence itself or the guarantee that the prosecution would not oppose a request for probation. The process of plea-bargaining after the crime is committed and the accused person is arrested. The accused pleads guilty in exchange of an agreed sentence recommended by the judge. There are three types of pleas bargains. These are charge bargaining, count bargaining and sentence bargaining. The first type of bargain is where the defendant agrees to plead to a charge that is lesser than the one he is charged with. The second is wh ere the defendant will have the number of charges that he faces reduced in number and the third is where the defendant simply pleads guilty with prior knowledge of what the sentence will be. The process of plea bargaining is a private matter where only the accused, the defendant counsel, the prosecutor and in some cases the judge may be in attendance. The offer of plea bargain is used to locate stolen goods, to help arrest other culprits or to know the location of a kidnapped victim or a killed individual. A plea bargain does not undermine the system of law. Although the facts indicate that the practice usually leads to reduced sentences to guilty parties without the process of trial, there are benefits that aid in offsetting the negative sentiments expressed in relation to the practice. There are many advantages to plea bargaining as there are disadvantages. Considering the success rates of plea bargaining compared to that of trials, the practice inadvertently aids in the reduction of criminals on the streets as well as guarantee speedy dispensation of justice (Goldstein, 1997). In exchange, the prosecution gets information that might be valuable to the conviction of more serious crimes or may get information that might be the missing link towards the conclusion of a case in a court or an investigation. There are instances where plea bargaining has been considered as lacking. The prisoner?s dilemma scenario plays out during plea bargains (Schulhofer, 1992). Consider two people who have been accused. The prosecution will attempt to unearth the facts of the case by offering a plea bargain to one party so that he can testify against the other party. Regardless of whether both parties are guilty or not, the person who confesses will give false information incriminating even those who may not be guilty in an attempt to get himself out of the larger sentence. Another scenario is when the defendant cannot raise bail. Such a defendant will plead guilty to the charges leveled against him regardless of whether he is guilty or not. Such a person considers the length of time that trials usually take and chooses to plead to a plea bargain that might present a lesser time than that which he would have faced awaiting trial. Some critics argue that plea bargaining does not always result in saving on costs (Kipnis, 1979). They consider that a prosecutor who has a remote chance of getting a conviction may enter a plea bargain with the aim of getting reduced time for the defendant. If such a defendant accepts the deal, he will increase the cost to the state as he will be catered for in a jail. On the contrary, if the trial had dragged on until the end, the defendant would have been acquitted and that would have carried no extra cost to the state. There are

Additive Manufacturing of Medical Implants: A Review

Additive Manufacturing of Medical Implants: A Review E. Gordon Wayne State University College of Engineering Abstract Additive manufacturing has numerous applications and is gaining interest in the biomedical field. The quality of additively manufactured parts is constantly improving, which contributes to their increased use for medical implants in patients. This paper reviews the literature on surgical additive manufacturing applications used on patients, with a focus on the customization of 3D printed implants and the ability to incorporate scaffolds on the implant surface. Scholarly literature databases were used to find general information on the focus topics, as well as case studies of surgical applications of additive manufacturing implants in rodents and humans. The advantages of additive manufacturing medical implants include improved medical outcome, cost effectiveness, and reduced surgery time, as well as customization and incorporated scaffold. Overall, the most effective type of additive manufacturing for the medical implant application is electron beam melting using Ti-6Al-4V because it can produce a high quality, high purity biocompatible implant that has the required mechanical properties. Keywords: Additive Manufacturing, Customized implants, Scaffold, 3D Printing, Ti-6Al-4V Introduction In recent years, additive manufacturing technologies have improved significantly, thus expanding the fields and applications for which they can be used. These 3D printing technologies create physical models from digital models without the need for tool and die and process planning. Additive manufacturing can fabricate prototypes of complex shapes in a variety of materials such as metals, polymers, and nylon. Metal components, in particular, can be used for practical applications such as medical implants: devices manufactured to replace or support a biological structure. The biocompatibility of these metallic devices must be considered, creating rigorous requirements for the material selection and final material properties of the structure. Studies have shown that additive manufacturing successfully produces implants with biocompatible materials that meet the structural requirements [1-6]. 3D printing medical implants can provide many benefits such as the customization and personalization of the implants, cost-effectiveness, increased productivity, and the ability to incorporate scaffold. Using custom made implants, fixtures and surgical tools can help decrease surgery time and patient recovery time, while increasing the likelihood of a successful surgery [7]. Another benefit is the cost efficiency of 3D printing medial implants. Traditional manufacturing methods are cheaper for large quantities, but are more expensive for personalized designs and small production runs [8, 9]. 3D printing is especially cost effective for small-sized implants like spinal or dental implants. 3D printing is also faster than traditional manufacturing if a custom implant needs to be made; traditional methods require milling, forging, and a long delivery time while 3D printing may only take about a day [1]. Another notable benefit of additive manufacturing is the ability to share data files of designs. Files saved as an .STL can be downloaded and printed anywhere in the world. The National Institutes of Health established a 3D Print Exchange to promote open-source sharing of 3D print files for medical models [7]. The most significant benefits for the biomedical industry, however, are the ability to manufacture biocompatible materials, customize implants, and incorporate a porous scaffold surface. Types of Additive Manufacturing The additive manufacturing approach uses computer software to slice a complex 3D model into layers of 2D cross-sections with a minute thickness. The layers are then printed layer by layer depending on the particular method chosen for the application. There are dozens of types of additive manufacturing systems on the market, some of the most common being stereolithography (SLA), direct metal laser sintering (DMLS), selective laser sintering (SLS), selective laser melting (SLM), 3D printing (3DP), and electron beam melting (EBM). These systems are classified according to the form of the raw material, which can be powder, liquid, or solid form [8]. The two types of additive manufacturing that are most commonly used for medical implants are SLS and EBM. Figure 1: Process chain for SLM and EBM. The pre-processing before manufacturing includes 3D modeling, file preparation, and slicing of the 3D model into layers. Post-processing may include heat treatment and polishing of fabricated parts [10]. Selective Laser Sintering An SLS printer uses a powder form of material for printing objects. A laser fuses a single layer of powder by drawing the shape of the object according to the first 2D cross-section of the 3D model. Immediately, the build platform is lowered by the defined layer thickness and another layer of powder is rolled across [10]. The process repeats, fusing each layer one at a time to form the object. SLS can be used with metal, ceramic, and plastic powders. The precision of the laser and the diameter of the powder determines the degree of detail of the final object, so it is possible to create detailed structures with an SLS printer [11]. Figure 2: Schematic of SLS system. The key components of SLM include the laser system (a fiber laser, F-theta and galvanometer used to control the laser beam movement) and the mechanical system (movable build platform and powder roller) [10]. Electron Beam Melting An EBM printer uses a powder form of material for printing objects, similar to SLS. However, while SLS uses a laser to fuse each layer of the powder, EBM uses an electron beam. This energy is delivered through an electric circuit between a tungsten filament inside of the electron gun and the build platform [10]. An electric current heats the filament to emit a beam of electrons [1]. Electric energy is transformed to heat energy which melts the powder on the build platform. The process continues similarly to SLS, where powder is spread across the platform in a thin layer, the cross-section of the object is melted, and then the build platform lowers by the layer thickness. A key element of EBM is that the build chamber is kept under vacuum, which allows the object to be maintain great detail (70-100ÃŽÂ ¼m) [1]. Figure 3: Schematic of EBM system. The key components of EBM include an electron beam system (electron gun assembly, electron beam focusing lens and deflection coils used to control the electron beam) and the mechanical system (movable powder rake and fixed powder cassettes) [10]. Materials of Medical Implants The most common metals used for surgical implants are stainless steel 316L (ASTM F138), Cobalt based alloys (ASTM F75 and ASTM F799) and titanium alloy Ti-6Al-4V (ASTM F67 and F136) [12, 13]. However, these metals have disadvantages such as the potential release of toxic ions and particles due to corrosion that cause inflammation and allergic reactions, affecting biocompatibility [14]. Also, the materials that have an elastic modulus that is not similar to natural bone stimulate new bone growth poorly [12]. Despite this, the low Youngs modulus, high strength, and nonlinear elasticity of titanium-based alloys make it the least harmful choice [3]. The most commonly used titanium alloy is Ti-6Al-4V (Ti64) because it also has a better resistance to corrosion compared to stainless steels and cobalt-based alloys [15]. Additive manufacturing has also been done using Tantalum. Tantalum is biocompatible, hard, ductile, and chemically resistant, but it is expensive and difficult to machine [6] . Titanium based alloys are superior, thus Ti-6Al-V4 is the best material for additive manufacturing medical implants. Material Youngs modulus (GPa) Ultimate tensile strength (MPa) Yield strength (MPa) Elongation (%) TiTa 75.77  ± 4.04 924.64  ± 9.06 882.77  ± 19.60 11.72  ± 1.13 Ti6Al4V 131.51  ± 16.40 1165.69  ± 107.25 1055.59  ± 63.63 6.10  ± 2.57 cpTi 111.59  ± 2.65 703.05  ± 16.22 619.57  ± 20.25 5.19  ± 0.32 Table 1: Tensile properties of SLS produced TiTa, Ti6Al4V and commercially pure titanium samples (n = 5) [16]. Customized Implants Additive manufacturing allows for the design and fabrication of customized prosthetic implants that are created to meet the specific needs of a patient, such as the size, shape, and mechanical properties of the implant. Additive Manufacturing reduces design time as well as manufacturing time because the implant pattern is computer generated with CT and MRI scans, thus removing the need for a physical model [8]. The ability to produce custom implants quickly solves a common problem with orthopedics where standard implants do not always fit the needs of certain patients. Previously, surgeons had to manually modify implants to make them fit the patient [7]. These techniques can be used by professionals in a variety of specialties such as neurosurgery, orthopedics, craniofacial and plastic surgery, oncology, and implant dentistry [8]. One example of an application in which a customized implant is required is craniofacial reconstruction. Craniofacial abnormalities are a diverse group of congenital defects that affect a large number of people and can be acquired at birth or due to injuries or tumors [8]. Standard cranial implants rarely fit a patient precisely because skulls have irregular shapes [7]. The custom implant can be created by using a CT scan to create a 3D virtual model of the patients skull. Then the model can be used with CAD software to design an implant that would perfectly fit the patient [8]. Using custom implants has shown to improve the morphology for large and complex-shaped cranial abnormalities, and some researchers have observed a greater improvement in neurological functions than after similar surgeries using traditionally manufactured implants [17, 18]. Figure 4: Skull model and customized implant for craniofacial reconstruction surgery [8]. Scaffold Additive manufacturing medical implants allows the porosity of the surface to be designed, controlled, and interconnected, which provides better bone growth into implants, thus decreasing the chances of the body rejecting the implant. Additionally, the rough surface quality of 3D printed implants enhances bone-implant fixation [1]. Without scaffold, there is a risk of bone weakening and bone loss around the implant, which is a consequence of stress shielding due to high stiffness of materials [19]. The probability of this problem occurring is lessened when bone can grow into a porous surface of the implant [19]. Cellular lattice structures are classified by stochastic and non-stochastic geometries. The pores in stochastic structures have random variations in size and shape, while the pores in non-stochastic structures have repeating patterns of particular shapes and sizes [10]. The main challenge in additively manufacturing scaffolds is the difficulty to remove the loose powder from within the pores, but an advantage is that additive manufacturing technology allows for the manufacturing of different types of scaffolds if a design requires it; different regions of the implant could have different porosities [1, 10]. The procedure used to achieve the porous areas with traditional manufacturing methods includes coating a smooth surface with other materials such as plasma-sprayed titanium or a titanium wire mesh; however, combining different metals increases the risk of the body rejecting the implant. Additive manufacturing allows the smooth and porous surfaces to be fabricated with the same material, thus decreasing that risk. A variety of additive manufacturing techniques can be used to create the lattice structure, but scaffold can be fabricated by SLS or EBM without the need for support structures, thus making it the most effective method [5]. Figure 5: Acetabular cup with designedFigure 6: (a) Porous femoral stem on the building porous surface [10].platform, (b) post-processed femoral stem [5]. Conclusion There are many advantages to using additive manufacturing to fabricate surgical implants. These benefits include improved medical outcome, cost effectiveness, reduced surgery time, as well as customization and scaffold. Overall, the most effective type of additive manufacturing for the medical implant application is Electron Beam Melting because it can produce a high quality, high purity biocompatible implant that has the required mechanical properties. The recommended metal to use for most implants is the titanium-based alloy Ti-6Al-4V because of its low Youngs modulus, high strength, nonlinear elasticity, and corrosion resistance. Overall, additive manufacturing is an excellent production method for medical implants because it allows surgeons to customize implants and scaffold to the specific needs of the patient. References 1.Petrovic, V., et al., Additive manufacturing solutions for improved medical implants. 2012: INTECH Open Access Publisher. 2.Ahn, Y.K., et al., Mechanical and microstructural characteristics of commercial purity titanium implants fabricated by electron-beam additive manufacturing. Materials Letters, 2017. 187: p. 64-67. 3.Yan, L.M., et al., Improved mechanical properties of the new Ti-15Ta-xZr alloys fabricated by selective laser melting for biomedical application. Journal of Alloys and Compounds, 2016. 688: p. 156-162. 4.Caldarise, S., Hip joint prostheses and methods for manufacturing the same. 1996, Google Patents. 5.Simoneau, C., et al., Development of a porous metallic femoral stem: Design, manufacturing, simulation and mechanical testing. Materials Design, 2017. 114: p. 546-556. 6.Wauthle, R., et al., Additively manufactured porous tantalum implants. Acta Biomaterialia, 2015. 14: p. 217-225. 7.Ventola, C.L., Medical Applications for 3D Printing: Current and Projected Uses. Pharmacy and Therapeutics, 2014. 39(10): p. 704-711. 8.Jardini, A.L., et al., Cranial reconstruction: 3D biomodel and custom-built implant created using additive manufacturing. Journal of Cranio-Maxillofacial Surgery, 2014. 42(8): p. 1877-1884. 9.DUrso, P.S., et al., Custom cranioplasty using stereolithography and acrylic. British Journal of Plastic Surgery, 2000. 53(3): p. 200-204. 10.Sing, S.L., et al., Laser and electronà ¢Ã¢â€š ¬Ã‚ beam powderà ¢Ã¢â€š ¬Ã‚ bed additive manufacturing of metallic implants: A review on processes, materials and designs. Journal of Orthopaedic Research, 2016. 34(3): p. 369-385. 11.Hoy, M.B., 3D printing: making things at the library. Med Ref Serv Q, 2013. 32(1): p. 94-9. 12.Kokubo, T., et al., Bioactive metals: preparation and properties. J Mater Sci Mater Med, 2004. 15(2): p. 99-107. 13.Staiger, M.P., et al., Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials, 2006. 27(9): p. 1728-1734. 14.Polo-Corrales, L., M. Latorre-Esteves, and J.E. Ramirez-Vick, Scaffold Design for Bone Regeneration. Journal of nanoscience and nanotechnology, 2014. 14(1): p. 15-56. 15.Dinda, G.P., L. Song, and J. Mazumder, Fabrication of Ti-6Al-4V Scaffolds by Direct Metal Deposition. Metallurgical and Materials Transactions a-Physical Metallurgy and Materials Science, 2008. 39A(12): p. 2914-2922. 16.Sing, S.L., W.Y. Yeong, and F.E. Wiria, Selective laser melting of titanium alloy with 50 wt% tantalum: Microstructure and mechanical properties. Journal of Alloys and Compounds, 2016. 660: p. 461-470. 17.Rotaru, H., et al., Cranioplasty With Custom-Made Implants: Analyzing the Cases of 10 Patients. Journal of Oral and Maxillofacial Surgery, 2012. 70(2): p. e169-e176. 18.Agner, C., M. Dujovny, and M. Gaviria, Neurocognitive Assessment Before and after Cranioplasty. Acta Neurochirurgica, 2002. 144(10): p. 1033-1040. 19.Shah, F.A., et al., Long-term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting. Acta Biomaterialia, 2016. 36: p. 296-309. Bacillus Thuringiensis: Distribution and Habitat Bacillus Thuringiensis: Distribution and Habitat LITERATURE REVIEW For several decades since its discovery, formulations of Bacillus thuringiensis (B. t.) have been seen as the ideal means of controlling Lepidoteran pests in agriculture because of the many attributes that differentiate this microbial insecticide from the synthetic chemical formulations. No toxicity to mammals, environmental friendliness, apparent immunity to the pesticide resistance phenomenon (no longer true), good integration with other pest control methods and the possibility of being mass produced at farm level at low cost, all made B. thuringiensis the much-needed tool for IPM programmes in developing countries. Research of almost 85 years reveals that Bacillus spp., especially B. thuringiensis and Bacillus sphaericus are the most potent biopesticides (Boucias Pendland, 1998). B. thuringiensis is a species of bacteria that has insecticidal properties that affects a specific range of insect orders. There are at least 34 subspecies of  B. thuringiensis (also called serotypes o r varieties) and possibly over 800 strain isolates (Swadener, 1994). B. thuringiensis accounts for about 5-8% of Bacillus spp. population in the environment (Hastowo et al., 1992). Till date more than 130 species of lepidopteran, dipteran and coleopteran insects are found to be controlled by  B. thuringiensis (Dean, 1984). Historical Background of B. thuringiensis B. thuringiensis are interesting and important bacteria used in the biological control of insect pest which form toxic crystal proteins at the time of sporulation. Perhaps the most well known and widely used biopesticide comes from B. thuringiensis, a bacterium that produces insecticidal proteins during its sporulation. This common soil bacterium, most abundantly found in grain dust from soil and other grain storage facilities, was discovered first in Japan in 1901 by Ishawata and then in 1911 in Germany by Berliner (Baum et al., 1999). It was subsequently found that thousands of strains of B. thuringiensis exist (Lereclus, 1993). The bacterium was isolated from diseased larvae of Anagasta kuehniella, and this finding led to the establishment of B. thuringiensis as microbial insecticide. The first record of its application to control insects was in Hungary at the end of 1920, and in Yugoslavia at the beginning of 1930s, it was applied to control the European corn borer (Lords, 2005). Sporine which was the first commercial product of B. thuringiensis was available in 1938 in France (Waiser, 1986) for the control of flour moth (Jacobs, 1951). Unfortunately, the product was used only for a very short time, due to World War II (Nester et al., 2002). Formation of transgenic plant was also observed. The first reports of insertion of genes encoding for B. thuringiensis delta-endotoxins into plants came in 1987 and the first transgenic plants to express B. thuringiensis toxins were tobacco and tomato plants (van Frankenhuyzen, 1993). In 1957 pacific yeast products commercialized the first strain on B. thuringiensis, named as Thuricide due to the increasing concern of biopesticide over the use of chemical insecticides. B. thuringiensis is a gram-positive spore-forming bacterium that produces crystalline proteins called deltaendotoxins during its stationary phase of growth (Schnepf et al., 1998). The crystal is released to the environment after analysis of the cell wall at the end of sporulation, and it can account for 20 to 30% of the dry weight of the sporulated cells (Schnepf et al., 1998) Distribution Habitat of B. thuringiensis This bacterium is distributed worldwide (Martin Travers, 1989). The soil has been described as its main habitat; however it has also been isolated from foliage, water, storage grains, and dead insects, etc (Iriarte Caballero, 2001). Isolation of strains from dead insects has been the main source for commercially used varieties, which include kurstaki, isolated from A. kuehniella; israelensis, isolated from mosquitoes, and tenebrionis, isolated from Tenebrio monitor larvae (Ninfa Rosas, 2009; Iriarte Caballero, 2001).. The spores of B. thuringiensis persist in soil, and vegetative growth occurs when nutrients are available (DeLucca et al., 1981; Akiba, 1986; Ohba Aizawa, 1986; Travers et al., 1987; Martin Travers, 1989). DeLucca et al., (1981) found that B. thuringiensis represented between 0.5% and 0.005% of all Bacillus species isolated from soil samples in the USA. Martin Travers (1989) recovered B. thuringiensis from soils globally. Meadows (1993) isolated B. thuringiensis from 785 of 1115 soil samples, and the percentage of samples that contained  B. thuringiensis ranged from 56% in New Zealand to 94% in samples from Asia and central and southern Africa. Ohba Aizawa (1986) isolated B. thuringiensis from 136 out of 189 soil samples in Japan. There are several theories on the ecological niche filled by B. thuringiensis. Unlike most insect pathogenic microbes, B. thuringiensis generally recycle poorly and rarely cause natural epizootics in insects, leading to speculation that B. thuringiensis is essentially a soil micro-organism that possesses incidental insecticidal activity (Martin Travers 1989). Evidence to support this view is that B. thuringiensis are commonly reported in the environment independent of insects and there is a lack of association between occurrence and insect activity (van Frankenhuyzen 1993). Meadows (1993) suggested four possible explanations for the presence of B. thuringiensis in soil: 1) rarely grows in soil but is deposited there by insects; 2) may be infective to soil-dwelling insects (as yet undiscovered); 3) may grow in soil when nutrients are available; and 4) an affinity with B. cereus. B. thuringiensis has been found extensively in the phylloplane. Numerous  B. thuringiensis subspecies have been recovered from coniferous trees, deciduous trees and vegetables, as well as from other herbs (Smith Couche, 1991; Damgaard et al., 1997). B. thuringiensis deposited on the upper side of leaves (exposed to the sun) may remain effective for only 1-2 days, but B. thuringiensis on the underside of leaves (i.e. protected from the sun) may remain active for 7-10 days (Swadner, 1994). B. thuringiensis kurstaki has been recovered from rivers and public water distribution systems after an aerial application of Thuricide 16B (Ohana, 1987). Crystal Composition and Morphology The existence of parasporal inclusions in B. thuringiensis was first noted in 1915 (Berliner, 1915), but their protein composition was not delineated until the 1950s (Angus, 1954). Hannay (1953) detected the crystalline fine structure that is a property of most of the parasporal inclusions. B. thuringiensis subspecies can synthesize more than one inclusion, which may contain different ICPs (Hannay, 1953). Depending on their ICP composition, the crystals have various forms (bipyramidal, cuboidal, flat rhomboid, or a composite with two or more crystal types) (Bulla et al., 1977; Hà ¶fte Whiteley, 1989). A partial correlation between crystal morphology, ICP composition, and bioactivity against target insects has been established (Bulla et al., 1977; Hà ¶fte Whiteley, 1989; Lynch Baumann, 1985). Classification of B. thuringiensis subspecies The classification of B. thuringiensis subspecies based on the serological analysis of the flagella (H) antigens was introduced in the early 1960s (de Barjac Bonnefoi, 1962). This classification by serotype has been supplemented by morphological and biochemical criteria (de Barjac, 1981). Until 1977, only 13 B. thuringiensis subspecies had been described, and at that time all subspecies were toxic to Lepidopteran larvae only. The discovery of other subspecies toxic to Diptera (Goldberg Margalit, 1977) and Coleoptera (Krieg et al., 1983) enlarged the host range and markedly increased the number of subspecies. Up to the end of 1998, over 67 subspecies based on flagellar H-serovars had been identified. Genetics of ICP In the early 1980s, it was established that most genes coding for the ICPs reside on large transmissible plasmids, of which most are readily exchanged between strains by conjugation (Gonzà ¡lez Carlton, 1980; Gonzà ¡lez et al., 1981). Since these initial studies, numerous ICP genes have been cloned, sequenced and used to construct  B. thuringiensis strains with novel insecticidal spectra (Hà ¶fte Whiteley, 1989). The currently known crystal (cry) gene types encode ICPs that are specific to either Lepidoptera (cryI), Diptera and Lepidoptera (cryII), Coleoptera (cryIII), Diptera (cryIV), or Coleoptera and Lepidoptera (cryV) (Hà ¶fte Whiteley, 1989). All ICPs described to date attack the insect gut upon ingestion. To date, each of the proteolytically activated ICP molecules with insecticidal activity has a variable C-terminal domain, which is responsible for receptrecognition (host susceptibility), and a conserved  N-terminal domain, which induces pore formation (toxicity) (Li et al., 1991). Most naturally occurring B. thuringiensis strains contain ICPs active against a single order of insects. However, conjugative transfer between B. thuringiensis strains or related species can occur, resulting in new strains with various plasmid contents (Gonzà ¡lez Carlton, 1980). Thus the mobility of the cry genes and the exchange of plasmids may explain the diverse and complex activity spectra observed in B. thuringiensis (Gonzà ¡lez Carlton, 1980; Gonzà ¡lez et al., 1981; Gonzà ¡lez et al., 1982; Reddy et al., 1987; Jarrett Stephenson, 1990). New B. thuringiensis strains have been developed by conjugation that is toxic to two insect orders. Nutritional status of B. thuringiensis Since sporulation and germination in bacilli are dependent on the nutritional status of the organism (Hardwick Foster, 1952), a study of the nutritional requirement of  B. thuringiensis var. thuringiensis is important for delineating the control mechanisms which regulate spore and parasporal crystal formation. Certain amino acids support growth, sporulation and crystal formation of B. thuringiensis var. thuringiensis, while others inhibit the growth (Singer et al., 1966; Singer Rogoff, 1968; Bulla et al., 1975; Nickerson Bulla, 1975; Rajalakshmi Shethna, 1977). A lower concentration of cystine (Nickerson Bulla, 1975) or cysteine (Rajalakshmi Shethna, 1977) promotes growth, sporulation and crystal formation in Î’. thuringiensis, while at a higher concentration of cys/cysSH, only the vegetative growth was observed, (Rajalakshmi Shethna, 1977). Classification of B. thuringiensis The classification of B. thuringiensis subspecies based on the serological analysis of the flagella (H) antigens was introduced in the early 1960s (de Barjac Bonnefoi, 1962). This classification by serotype has been supplemented by morphological and biochemical criteria (de Barjac, 1981). Many strains of B. thuringiensis have been isolated and classified within more than 20 different varieties by serological techniques. On the basis of their potency for insect these varieties have been grouped into five pathotypes: Lepidopteran-Specific (e.g. B. thuringiensis .var Kurstaki) Dipteran-Specific (e.g. B. thuringiensis . var israelensis) Coleopteran-Specific (e.g. B. thuringiensis .var. tenebrionis) Those active against Lepidoptera and Dipter(e.g. B. thuringiensis . var. aizawai) Those with no toxicity recorded in insects (e.g. B. thuringiensis . var. Dakota) Mode of Action The ICP structure and function have been reviewed in detail by Schnepf et al., (1998). Binding of the ICP to putative receptors is a major determinant of ICP specificity and the formation of pores in the midgut epithelial cells is a major mechanism of toxicity (Van Frankenhuyzen, 1993). After ingestion of B. thuringiensis by insect the crystal is dissolved in the insects alkaline gut. Then the digestive enzymes that are present in insects body break down the crystal structure and activate B. thuringiensiss insecticidal component, called the delta-endotoxin (Swadner, 1994). The delta-endotoxin binds to the cells lining the midgut membrane and creates pores in the membrane, upsetting the guts ion balance. The insect soon stops feeding and starves to death (Gill et al., 1992). Target Organisms In the past decades, B. thuringiensis Cry toxins were classified according to the target pest they attacked (Hofte Whiteley, 1998); however, due to the dual toxic activity exhibited by some cry genes and the inconsistencies in the original classification proposed by Hà ¶fte and Whiteley(1998), Crickmore et al., (1998) proposed a revision of the nomenclature for insecticidal crystal proteins, based on the ability of a crystal protein to exhibit some experimentally verifiable toxic effect in a target organism (Crickmore et al., 1998; Hà ¶fte Whiteley, 1998). The diversity of B. thuringiensis is demonstrated in the almost 70 serotypes and the 92 subspecies described to date (Galan-Wong et al., 2006). It is well known that many insects are susceptible to the toxic activity of  B. thuringiensis; among them, lepidopterans have been exceptionally well studied, and many toxins have shown activity against them (Jarret Stephens., 1990; Sefinejad et al., 2008). Order Lepidoptera encompasses the majority of susceptible species belonging to agriculturally important families such as Cossidae, Gelechiidae, Lymantriidae, Noctuidae, Pieridae, Pyralidae, Thaumetopoetidae, Tortricidae, and Yponomeutidae (Iriarte Caballero, 2001). General patterns of use: Commercial applications of B. thuringiensis have been directed mainly against lepidopteran pests of agricultural and forest crops; however, in recent years strains active against coleopteran pests have also been marketed (Tomlin, 1997). Strains of B. thuringiensis kurstaki active against dipteran vectors of parasitic disease organisms have been used in public health programmes (Tomlin, 1997). Applications in agriculture and forestry Commercial use of B. thuringiensis on agricultural and forest crops dates back nearly  30 years, when it became available in France (Van Frankenhuyzen, 1993). Use of  B. thuringiensis has increased greatly in recent years and the number of companies with a commercial interest in B. thuringiensis products has increased from four in 1980 to at least 18 (Van Frankenhuyzen, 1993). Several commercial B. thuringiensis products with B. thuringiensis aizawai, B. thuringiensis kuehniella or B. thuringiensis tenebrionise have been applied to crops using conventional spraying technology. Various formulations have been used on major crops such as cotton, maize, soybeans, potatoes, tomatoes, various crop trees and stored grains. Formulations have ranged from ultralow-volume oil to high-volume, wettable powder and aqueous suspensions (Tomlin, 1997). In the main, naturally occurring B. thuringiensis strains have been used, but transgenic microorganisms expressing B. thuringiensis toxins have been developed by conjugation and by genetic manipulation, and in some cases, these have reached the commercial market (Carlton et al., 1990). These modified organisms have been developed in order to increase host range, prolong field activity or improve delivery of toxins to target organisms. For example, the coleopteran-active cryIIIA gene has been transferred to a lepidopteran-active B. thuringiensis kuehniella (Carlton et al., 1 990). A plasmid bearing an ICP gene has been transferred from B. thuringiensis to a non-pathogenic leaf-colonizing isolate of Pseudomonas fluorescens; fixation of the transgenic cells produces ICP contained within a membrane which prolongs persistence (Gelernter, 1990). Applications in vector control B. thuringiensis Kurstaki has been used to control both mosquitos and blackflies in large-scale programmes (Lacey et al., 1982; Chilcott et al., 1983; Car, 1984; Car de Moor, 1984; Cibulsky Fusco, 1987; Becker Margalit, 1993; Bernhard Utz, 1993). For example, in Germany 23 tonnes of B. thuringiensis Kurstaki wettable powder and 19 000 litres of liquid concentrate were used to control mosquitos (Anopheles and Culex species) between 1981 and 1991 in the Upper Rhine Valley (Becker Margalit, 1993). In China, approximately 10 tonnes of B. thuringiensis Kurstaki have been used in recent years to control the malarial vector, Anopheles sinensis. Resistance of Insect Populations A number of insect populations of several different species with different levels of resistance to B. thuringiensis have been obtained by laboratory selection experiments during the last 15 years (Schnepf et al., 1998). The species include Plodia interpunctella, Cadra cautella, Leptinotarsa decemlineata, Chrysomela scripta, Tricholplusia ni, Spodoptera littoralis, Spodoptera exigua, Heliothis virescens, Ostrinia nubilalis and Culex quinquefasciatus (Schnepf et al., 1998). The Indian meal moth, a pest of grain storage areas, was the first insect to develop resistance to B. thuringiensis. Kurstaki (Swadner, 1994). Resistance progresses more quickly in laboratory experiments than under field conditions due to higher selection pressure in the laboratory (Tabashnik, 1991). No indications of insect resistance to B .thuringiensis were observed in the field, until the development of resistance was ob-served in the diamondback moth in crops where B. thuringiensis had been used repeatedly. Since then, resistance has been observed in the laboratory in the tobacco budworm, the Colorado potato beetle and other insect species (McGaughey, 1992) B. thuringiensiss Ecological Impacts Some of the most serious concerns about widespread use of B. thuringiensis as a pest control technique come from the effects it can have on animals other than the pest targeted for control. All B. thuringiensis products can kill organisms other than their intended targets. In turn, the animals that depend on these organisms for food are also impacted (Swadner, 1994). Effect on Beneficial insects: Many insects are not pests, and any pest management technique needs to be especially concerned about those that are called beneficials, the insects that feed or prey on pest species (Swadner, 1994). B. thuringiensis has impacts on a number of beneficial species. For example, studies of a wasp that is a parasite of the meal moth (Plodia interpunctella) found that treatment with B. thuringiensis reduced the number of eggs produced by the parasitic wasp, and the percentage of those eggs that hatched (Salama, 1993). Production and hatchability of eggs of a predatory bug were also decreased (Salama, 1991). Other insects: Many insects that do not have as directly beneficial importance to agriculture are important in the function and structure of ecosystems. A variety of studies have shown that B. thuringiensis applications can disturb insect communities (Swadner, 1994). Research following large-scale B. thuringiensis applications to kill gypsy moth larvae in Lane County, Oregon, found that the number of oak-feeding caterpillar species was reduced for three years following spraying, and the number of caterpillars was reduced for two years (Miller, 1990). Birds: Because many birds feed on the caterpillars and other insects affected by B. thuringiensis applications, it is not surprising that impacts of B. thuringiensis spraying on birds have been documented (Swadner, 1994). In New Hampshire, when B. thuringiensis-treatment reduced caterpillar abundance, black-throated blue warblers made fewer nesting attempts and also brought fewer caterpillars to their nestlings (Rodenhouse, 1992). Effects on Humans Eight human volunteers ingested 1 gram of a B. thuringiensis kuehniella formulation  (3 ÃÆ'- 109 spores/g of powder) daily for 5 days. Of the eight volunteers, five also inhaled 100 mg of the B. thuringiensis kuehniella powder daily for five days. Comprehensive medical examinations immediately before, after, and 4 to 5 weeks later failed to demonstrate any adverse health effects, and all the blood chemistry and urinalysis tests were negative (Fisher Rosner, 1959). Pivovarov et al., (1977) reported that ingestion of foods contaminated with  B. thuringiensis gastroenteitis at concentrations of 105 to 109 cells/g caused nausea, vomiting, diarrhoea and tenesmus, colic-like pains in the abdomen, and fever in three of the four volunteers studied. The toxicity of the B. thuringiensis gastroenteritis strain may have been due to beta-exotoxin (Ray, 1990). In a purified form, some of the proteins produced by B. thuringiensis are acutely toxic to mammals. However, in their natural form, acute toxicity of commonly-used  B. thuringiensis varieties is limited to caterpillars, mosquito larvae, and beetle larvae (Swadner, 1994). Special Concerns about B. thuringiensis Toxicity The earliest tests done regarding B. thuringiensiss toxicity were conducted using B. thuringiensis var. thuringiensis, a B. thuringiensis strain known to contain a second toxin called beta-exotoxin (Swadner, 1994). The beta-exotoxin is toxic to vertebrates, with an LD 50 (median lethal dose; the dose that kills 50 percent of a population of test animals) of 13-18 milligrams per kilogram of body weight (mg/kg) in mice when injected into the abdomen. An oral dose of 200 mg/kg per day killed mice after eight days (swadner, 1994) Beta-exotoxin also causes genetic damage to human blood cells (Meretoja, 1977).